Kyle Traynor is set to make his first Premiership start when Bristol Rugby face Exeter on Friday evening (7.45pm KO).
The Scotland international is one of six changes, all in the pack, for the South-West derby at Ashton Gate.
Andy Robinson names an unchanged backline as Bristol look to end a run of three successive defeats in the Aviva Premiership.
In the forwards, Gaston Cortes returns to the front row, while James Phillips and Mark Sorenson form a new-look second row partnership.
Jon Fisher recovers from a toe injury to start in the back row and Jordan Crane also returns.
“It’s great to have Friday night rugby back at Ashton Gate and we’re buoyed by the knowledge that there will be a bumper crowd to support the team,” Robinson said.
“The key messages to the squad this week has been to stick together, keep fighting and keep working hard. We know where we need to improve and we’re looking to embrace the challenge that Exeter Chiefs will bring under the floodlights.”
Ben Mosses (knee) is sidelined for up to twelve weeks and the centre is joined by Gavin Henson (dead leg), Ben Glynn (shoulder), Marc Jones (knee), David Lemi (knee), Callum Sheedy (hamstring), Glen Townson (knee) and Ryan Bevington (head).
Max Crumpton, Jamal Ford-Robinson and Charlie Amesbury are all named among the replacements and could make their first competitive outings of the campaign if they feature.
Bristol Rugby team to face Exeter Chiefs at Ashton Gate on Friday, 23 September (7.45pm KO):
15. Jordan Williams; 14. Ryan Edwards, 13. Will Hurrell, 12. Thretton Palamo, 11. Tom Varndell; 10. Tusi Pisi, 9. Will Cliff; 1. Kyle Traynor, 2. Ross McMillan, 3. Gaston Cortes, 4. James Phillips, 5. Mark Sorenson, 6. Jon Fisher, 7. Jack Lam (c), 8. Jordan Crane.
Replacements: 16. Max Crumpton, 17. Soane Tonga’uiha, 18. Jamal Ford-Robinson, 19. Joe Joyce, 20. Mitch Eadie, 21. Martin Roberts, 22. Adrian Jarvis, 23. Charlie Amesbury.